Endocrine Abstracts

Introduction: In this study, we aimed to evaluate the effects of fat distribution and some adipokines on insulin resistance (IR) in prediabetic patients.Materials and Methods: cases were divided into three groups according to 75 gr-oral glucose tolerance test (OGTT) results [27 cases impaired fasting glucose (IFG), 36 cases impaired glucose tolerance (IGT) and 24 healthy control subjects]. Serum fasting insulin levels and lipid parameters were measured. ...

Aim: The aim of this study was to investigate the relationship between the clinical and laboratory findings of metabolic bone disease regarding the levels of osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa B ligand (RANKL) in the patients with diabetic nephropathy.Material and method: This study includes 61 type 2 diabetic patients and age-, sex-matched 20 healthy subjects. Diabetic patients were divided into three groups accordi...

Previous gestational diabetes mellitus (pGDM) is associated with insulin resistance which is a well-known risk factor for atherosclerotic diseases. Mean platelet volume (MPV) is an indicator of platelet activation which plays a crucial role in pathogenesis of atherosclerosis.One hundred and five consecutive women with pGDM and 40 healthy women with normal previous pregnancies were included in the study. At the time of enrollment, anthropometric measureme...

Background: The symptoms typically associated with polycystic ovary syndrome (PCOS) such as acne, hirsutism, irregular menses, amenorrhoea, obesity and infertility are a major source of psychological morbidity and can negatively affect quality of life (QOL). Limited data are available regarding effects of different treatment modalities on emotional distress of women with PCOS.Objective: To determine potential impact of treatment on health-related quality...

Background: Hyperprolactinemia is frequently reported with polycystic ovary syndrome (PCOS). However, there is a controversy whether they share a common mechanism or have cause–result relationship or just are coincidental. The objective of the present study was to identify the cause of hyperprolactinemia in patients with PCOS.Methods: We retrospectively evaluated our outpatient admission records for PCOS, hirsutism, oligomenorrhea, or secondary amen...

Diabetes mellitus (DM) includes a group of carbohydrate metabolism disorders that is characterized by hyperglycemia and leads long-term macro- and microvascular complications. Also siblings of type 2 diabetic patients have increased relative risk of micro and macrovasculer outcome of DM even though their plasma glucose levels in normal range. Genetically determined hyperinsulinemia, insulin resistance and associated dyslipidemia have crucial role in the processes of vascular a...

Background: and ObjectiveThyroid collision tumors are extremely rare, accounting for just around 1% of all thyroid carcinomas. The objective of this study is to enhance our understanding of the clinical characteristics of these infrequently reported occurrences. In our study, we evaluated the clinical features of medullary thyroid carcinoma (MTC) that existed synchronously with papillary thyroid carcinoma (PTC).Methods: We performed a retrospective anal...

Introduction: Diabetic ketoacidosis is a metabolic event that occurs as a result of the absence or deficiency of insulin and the increase in contrinsuliner hormones, resulting in disruption of electrolyte and water regulation. In this study, it was planned to investigate the changes in ANP, copeptin, renin, aldosterone levels before and after rehydration and insulin therapy in pediatric patients with a diagnosis of diabetic ketoacidosis followed in the pediatr...

Introduction: Familial partial lipodystrophy (FPL) is a rare genetic disorder characterised by a selective lack of subcutaneous fat that is associated with insulin resistance and diabetes. FPL has been reported to be caused by mutations in the peroxisome proliferator activator receptor-γ (PPARG) gene, which encodes a key transcription factor that regulates adipocyte differentiation and insulin sensitivity.Material and methods: The objective of this ...

Objective: Rosacea is an inflammatory dermatosis. Telangiectasias, edema, erythema, and acneiform eruptions are the main symptoms. Several genetic and environmental factors have been linked to rosacea; however, the etiology of the disease is still not known. It is considered a systemic disease rather than a skin disorder. Endocrine-disrupting chemicals are substances people are exposed to through water, food, self-care products, and the environment. They interfere with normal ...